Direct catalytic asymmetric aminoallylation of aldehydes: synergism of chiral and nonchiral Brønsted acids.
نویسندگان
چکیده
The development of a catalytic asymmetric method for the direct aminoallylation of aldehydes is described that gives high asymmetric inductions for a broad range of substrates including both aromatic and aliphatic aldehydes. This method allows for direct isolation of unprotected analytically pure homoallylic amines without chromatography. The unique catalyst system developed for this process involves the synergistic interaction between a chiral and a nonchiral Brønsted acid.
منابع مشابه
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ورودعنوان ژورنال:
- Journal of the American Chemical Society
دوره 133 15 شماره
صفحات -
تاریخ انتشار 2011